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The evaluation of local toxicity endpoints such as skin and eye irritation, skin sensitisation and phototoxicity is an extremely important part of the safety assessment of cosmetics because many cosmetic products are applied on the skin or around the eyes.
The third module of the CTPA Safety Assessment Campaign 2021 explains toxicological considerations and test methods to assess local toxicity endpoints including skin irritation, eye irritation, skin sensitisation and phototoxicity. The module covers the following key topics:
- The principles behind skin irritation and how to assess the skin irritation potential of cosmetic ingredients and products using clinical tests, user trials and in vitro tests including a practical case study.
- The principles behind eye irritation and different in vitro test methods to assess the eye irritation potential of cosmetic ingredients and products.
- The principles behind skin sensitisation, key information requirements, in vitro and in vivo test methods and other data sources to assess the skin sensitisation potential of cosmetic ingredients including a practical case study.
- The principles behind phototoxicity, key factors to consider while assessing the phototoxic potential of cosmetic ingredients, followed by chemical and in vitro test methods to assess phototoxicity.
Please contact Sameer Mehandale for further information.